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Apt 1

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By Targets:	Apoptosis (1) Autophagy (1) Beclin1 (1) MAGL (1) Necroptosis (1) Phospholipase (3) RIP kinase (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1)

4

Inhibitors & Agonists

12

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Apostatin-1 Apt-1	RIP kinase Autophagy Apoptosis Beclin1 Necroptosis	Inflammation/Immunology
Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (K_D=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin .

ML348 4 Publications Verification GNF-Pf-1127	Phospholipase	Cancer
ML348 (GNF-Pf-1127) is a selective and reversible *acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1)* inhibitor with an IC₅₀ of 210 nM, and barely inhibits LYPLA2 .

ML-211	Phospholipase MAGL
ML-211 is a carbamate-based dual inhibitor of *acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1)* (IC₅₀=17 nM) and LYPLA2 (IC₅₀=30 nM). ML-211 also inhibits theserine hydrolase ABHD11 with an IC₅₀ value of 10 nM but is ≥ 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases .

Palmostatin B	Phospholipase	Cancer
Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, *APT-2*) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells .

Species:	Human (6) Rat (2) Mouse (2) Cynomolgus (2)
Tag:	His (5) Tag Free (3) Fc (4)
Source:	HEK293 (8) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

	Fas/CD95 Protein, Human (HEK293, His) rHuTumor necrosis factor receptor superfamily member 6/TNFRSF6, His; Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; Apt1; FAS1; TNFRSF6 and FAS	Human	HEK293
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Human Fas receptor contain a death domain (230-314 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Human (HEK293, His) has a full length of 147 amino acids (Q26-N173), produced in HEK293 cells with C-terminal 6*His-tag.

	Fas/CD95 Protein, Cynomolgus (HEK293, Fc) Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; CD95; FAS; Apt1; FAS1; TNFRSF6	Cynomolgus	HEK293
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Macaca mulatta Fas receptor contain a death domain (228-312 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Cynomolgus (HEK293, Fc) has a full length of 173 amino acids (M1-D173), produced in HEK293 cells with C-terminal hFc-tag.

	Fas/CD95 Protein, Rat (HEK293, His) Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; CD95; FAS; Apt1; FAS1; TNFRSF6	Rat	HEK293
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Rat Fas receptor contain a death domain (219-303 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Rat (HEK293, His) has a full length of 170 amino acids (M1-K170), produced in HEK293 cells with C-terminal 6*His-tag.

	Fas/CD95 Protein, Rat (HEK293, Fc) Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; CD95; FAS; Apt1; FAS1; TNFRSF6	Rat	HEK293
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Rat Fas receptor contain a death domain (219-303 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Rat (HEK293, Fc) has a full length of 170 amino acids (M1-K170), produced in HEK293 cells with C-terminal 6*hFc-tag.

	Fas/CD95 Protein, Human (HEK293, Fc) Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; CD95; FAS; Apt1; FAS1; TNFRSF6	Human	HEK293
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Human Fas receptor contain a death domain (230-314 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Human (HEK293, Fc) has a full length of 173 amino acids (M1-N173), produced in HEK293 cells with C-terminal hFc-tag.

	Fas/CD95 Protein, Human (HEK293) rHuFASR/TNFRSF6; Tumor necrosis factor receptor superfamily member 6; Fas receptor; CD95; Apt1; FAS1; Apo-1	Human	HEK293
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Human Fas receptor contain a death domain (230-314 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Human (HEK293) has a full length of 157 amino acids (Q26-S172), produced in HEK293 cells with tag free.

	Fas/CD95 Protein, Cynomolgus (HEK293) Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; CD95; FAS; Apt1; FAS1; TNFRSF6	Cynomolgus	HEK293
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Macaca mulatta Fas receptor contain a death domain (228-312 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Cynomolgus (HEK293) has a full length of 173 amino acids (M1-D173), produced in HEK293 cells with tag free.

	Fas/CD95 Protein, Human rHuFASR/TNFRSF6; Tumor necrosis factor receptor superfamily member 6; Fas receptor; CD95; Apt1; FAS1; Apo-1	Human	E. coli
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Human Fas receptor contain a death domain (230-314 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Human has a full length of 157 amino acids (R17-N173), produced in E.coli with tag free.

	Fas/CD95 Protein, Mouse (HEK293, Fc) FASLG receptor; CD95; Apt1; FAS1; TNFRSF6; FAS; ALPS1A; APO1; FASTM; FasR	Mouse	HEK293
	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD). Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases. Mouse Fas receptor contain a death domain (222-306 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Mouse (HEK293, Fc) has a full length of 148 amino acids (Q22-R169), produced in HEK293 cells with C-terminal hFc-tag.

	APT-1/LYPLA1 Protein, Human (His) rHuApt-1, His; LYPLA1; Apt-1	Human	E. coli
	APT-1/LYPLA1 protein, an acyl-protein thioesterase, hydrolyzes fatty acids from S-acylated cysteine residues in proteins, including G alpha proteins and HRAS. It also depalmitoylates KCNMA1 and potentially ADRB2, while functioning as a lysophospholipase, hydrolyzing lysophosphatidylcholine (lyso-PC) and other lysophospholipids (lyso-PE, lyso-PI, lyso-PS). APT-1/LYPLA1 significantly influences blood coagulation by cleaving plasma phospholipids, generating lysophospholipids for ENPP2, leading to lysophosphatidic acid (LPA) production. APT-1/LYPLA1 Protein, Human (His) is the recombinant human-derived APT-1/LYPLA1 protein, expressed by E. coli, with N-6*His labeled tag. The total length of APT-1/LYPLA1 Protein, Human (His) is 230 a.a., with molecular weight of ~25.0 kDa.

HY-P700052AF

	Animal-Free FasL Protein, Human (His) soluble Fas Ligand (sFasL); TNFSF6; CD95L; Apo I Ligand; AptL; Apt1LG1; CD178	Human	E. coli
	Fas Ligand (CD178; APTL) is a ligand to TNFRSF6/FAS/CD95, transduces the apoptotic signal to regulate cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Human Fas Ligand exhibits 4 isoforms, the soluble form (130-281 a.a.) of which plays an important role in the activation-induced cell death (AICD) of T lymphocytes Jurkat cells. However the membrane-bound isoform could be responsible for its inflammatory activity. Animal-Free FasL Protein, Human (His) has a total length of 152 amino acids (Q130-L281), is expressed in E. coli with N-terminal His-tag.

HY-P700176AF

	Animal-Free Fas Ligand Protein, Mouse (His) soluble Fas Ligand (sFasL); TNFSF6; CD95L; Apo I Ligand; AptL; Apt1LG1; CD178; Fas-Lg; Tnfs; Tnlg1a; gld	Mouse	E. coli
	The cytoplasmic form of Fas ligand protein exerts powerful effects by inhibiting gene transcription. This protein plays a crucial role in regulating cellular processes by inhibiting the expression of specific genes. Animal-Free Fas Ligand Protein, Mouse (His) is the recombinant mouse-derived animal-FreeFas Ligand protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free Fas Ligand Protein, Mouse (His) is 152 a.a., with molecular weight of ~18.14 kDa.

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